Table III.
T Cell Composition of Colonic Lymphoid Follicles, Cecal Patches, and Peyer's Patches from IFN-γ+/+ and IFN-γ−/− Mice with TNBS Colitis
| CD3+ T cells | Colonic lymphoid follicles | Cecal patches | Peyer's patches | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IFN-γ+/+ | IFN-γ−/− | IFN-γ+/+ | IFN-γ−/− | IFN-γ+/+ | IFN-γ−/− | |||||||
| CD4−CD8+ | 6.7 ± 2.7 (4.5) | 5.9 ± 0.8 (2.0) | 5.1 ± 0.2 | 9.2 ± 3.5 | 6.4 ± 0.8 | 6.7 ± 0.3 | ||||||
| CD4+CD8− | 19.7 ± 3.8 (28.9) | 18.8 ± 2.4* (24.3) | 26.4 ± 2.3 | 31.9 ± 4.9* | 29.7 ± 3.9 | 26.2 ± 1.0* | ||||||
| CD4+CD8+ | 0.2 ± 0.0 (0.56) | 0.8 ± 1.0 (0.83) | 0.1 ± 0.0 | 1.2 ± 0.2 | 0.7 ± 0.3 | 0.7 ± 0.3 | ||||||
| CD4−CD8− | 1.3 ± 1.7 (2.8) | 0.7 ± 0.1 (1.1) | 2.6 ± 1.3 | 1.8 ± 0.9 | 1.2 ± 0.5 | 1.0 ± 0.6 | ||||||
| α/β-TCR+ | 29.6 ± 3.3 (26.0) | 28.8 ± 3.0 (23.2) | 34.2 ± 3.0 | 42.6 ± 7.5 | 32.9 ± 04.5 | 36.1 ± 1.4 | ||||||
| γ/δ-TCR+ | 0.5 ± 0.1 (1.2) | 0.8 ± 0.1 (1.7) | 0.5 ± 0.1 | 0.5 ± 0.0 | 0.7 ± 0.2 | 0.8 ± 0.2 | ||||||
Values shown are the average ± 1 SD of the percentage of mononuclear cells in three independently prepared cell fractions. Values shown in parentheses are for colonic lymphoid follicles from naive mice and were obtained from pooled cell fractions from 10 mice.
*
P < 0.05.