Table I.
mAb PAL-1 Inhibits AM Binding of a Panel of Unopsonized Particles
| Particle | Percent inhibition | |
|---|---|---|
| TiO2 (n = 10) | 67 ± 5 | |
| Fe2O3 (n = 2) | 78 ± 2 | |
| Sulfated latex beads (n = 2) | 85 ± 3 | |
| SiO2 (n = 3) | 52 ± 24 |
Hamster AMs were left untreated or pretreated with mAb PAL-1 or an isotype-matched control mAb and their binding of particles determined as described in Materials and Methods. Particle binding is expressed as percent inhibition of TiO2 (n = 10), Fe2O3 (n = 2), latex bead (n = 2), and SiO2 (n = 3) binding by mAb PAL-1. No significant inhibition of particle binding was observed with a control IgM (range is from −18 to 7% inhibition).