Figure 3.
Antigen specificity of downregulation of immune response elicited by immunization with high doses of gp96. (A) The experimental plan used to measure the effect of immunization with gp96 on concomitant immunity; see text for details. (B) Immunization with high doses (10 μg i.d.) of Meth A gp96 but not liver gp96 elicits loss of concomitant immunity to Meth A sarcoma. Corresponding experiments were also carried out with subcutaneous administrations of gp96 with similar results (data not shown).