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. 1999 Jun 7;189(11):1699–1706. doi: 10.1084/jem.189.11.1699

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Effects of anti–TNF-α and anti–IL-1β antibodies on infarct size (top) and Mn-SOD activity (bottom). Anti-murine TNF-α and/or anti-murine IL-1β antibodies were infused intraperitoneally 30 min before exercise. 0.5 or 48 h after exercise (EX), rats were subjected to occlusion of the LCA followed by reperfusion. C 0.5h and C 48h indicate sham-treated control 0.5 and 48 h after sham treatment, respectively. The size of the myocardial infarct was measured 48 h after reperfusion (n = 6–10). The activity of Mn-SOD (n = 4–5) was evaluated 0.5 or 48 h after exercise. Data are expressed as mean ± SEM; *P < 0.05 vs. corresponding sham-treated control; ⁺ P < 0.05 vs. without the antibodies by one-way ANOVA with Bonferroni's post hoc test for multiple comparisons.