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. 1999 Jun 7;189(11):1699–1706. doi: 10.1084/jem.189.11.1699

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Effects of TNF-α on size of myocardial infarct (top) and activity of Mn-SOD (bottom). After the intravenous injection of rTNF-α, rats were subjected to LCA occlusion followed by reperfusion at the times indicated. Infarct size was evaluated 48 h after reperfusion (n = 7–9). The activity of Mn-SOD was measured at the indicated times after TNF-α administration (n = 4). C, untreated control 0.5 h after vehicle (saline) injection. Data are expressed as mean ± SEM; *P < 0.05 vs. control (C) by one-way ANOVA with Bonferroni's post hoc test for multiple comparisons.