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Neutrophil granule expression during myelopoiesis and abnormalities in neutrophil-specific granule deficiency (broken arrows). The contents of primary granules, with the exception of defensins, are present in SGD neutrophils; however, secondary and tertiary granules are absent. G-CSF induces C/EBPε early in myelopoiesis, which initiates transcription of granule components as indicated.
