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. 2000 Dec 4;192(11):1625–1636. doi: 10.1084/jem.192.11.1625

Figure 2.

Histopathological analysis of nonirradiated and irradiated wt and G5 mTR−/− mice. Bone, stomach, small intestine, and kidney histological sections corresponding to nonirradiated and irradiated wt and G5-mTR−/− mice are shown. Only the irradiated moribund G5 mTR−/− mice showed radiation-induced pathologies such as dramatic BM aplasia, degeneration of parietal cells, and cystic formation in the stomach, acute atrophy of the villi with crypt degeneration in the small intestine, and acute degeneration of kidney tubules (see arrows indicating abnormalities). Differences in staining are due to slight differences in the thicknesses of the sections. All images were taken at the same magnification (99×) except BM (150×). Sections were fixed in 10% buffered formalin and stained with hematoxylin–eosin.

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