Table 4.
Normalized Frequencies of Chromosomal Aberrations in BM Cells of wt and G2 and G5 mTR−/− Mice
| Genotype: | wt | G2 mTR−/− | G5 mTR−/− | |||
|---|---|---|---|---|---|---|
| Treatment | Control | Irradiated | Control | Irradiated | Control | Irradiated |
| Telomeric associations | 0 | 0 | 0 | 0 | 7.2 | 8.1 |
| End–end fusions | ||||||
| Robertsonian fusions | ||||||
| Interhomolgue | 0 | 0 | 0 | 0 | 0 | 7 |
| Interchromosome | 0 | 0 | 0 | 0 | 0.6 | 3.9 |
| Dicentrics (q-q arm) | 0 | 0 | 0 | 0 | 0.3 | 3.5 |
| Total | 0 | 0 | 0 | 0 | 0.9 | 14.4 |
| Other chromosome-type aberrations | ||||||
| Reciprocal translocations | 0 | 2 | 0 | 2.2 | 0 | 2.3 |
| Terminal translocations | 0 | 0.5 | 0 | 2.2 | 0.9 | 1.2 |
| Complex translocations | 0 | 0 | 0 | 0 | 0.3 | 0 |
| Deletions | 0.7 | 1 | 0 | 0 | 0 | 2.3 |
| Bicolored fragments | 0 | 0 | 0 | 0 | 0 | 0.4 |
| Total | 0.7 | 3.5 | 0 | 4.4 | 1.2 | 4.2 |
| Chromatid-type aberrations | ||||||
| Chromatid breaks | 0.7 | 0.5 | 0 | 0 | 0.3 | 1.2 |
| Isochromatid breaks | 0 | 0 | 0 | 2.2 | 0 | 0.8 |
| Chromatid exchanges | 0 | 0 | 0 | 0 | 0 | 0.4 |
| Intra-arm intrachanges | 0 | 0 | 0 | 0 | 0.6 | 0 |
| Total | 0.7 | 0.5 | 0 | 2.2 | 0.9 | 2.4 |
| Whole chromosome losses/gains | ||||||
| −1 | 4.3 | 8 | 0 | 8.7 | 6.6 | 12.4 |
| +1 | 0.7 | 0.5 | 0 | 0 | 0 | 3.5 |
| +2 | 0 | 0 | 0 | 0 | 0 | 1.2 |
| Total | 5.0 | 8.5 | 0 | 8.7 | 6.6 | 17.1 |
| No. cells scored | 146 | 200 | 25 | 46 | 347 | 259 |
| No. animals | 2 | 2 | 1 | 1 | 4 | 4 |