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Effect of IFN-γ on respiratory antiproteases. RT-PCR was used to compare the levels of mRNA encoding respiratory-relevant antiproteases in 2-mo-old transgene-negative and transgene-positive CC10-rtTA-IFN-γ mice that received either normal water (−) or dox water (+) from 1–2 mo of age. The lack of effect of IFN-γ on TIMP-1, -2, and -3, and α1-AT, and the ability of IFN-γ to inhibit SLPI can be appreciated.
