Figure 3.

Absence of bladder contraction in response to nicotine in α3-deficient mice. (a) Typical tracings of the response to nicotine and CCH in +/+ and −/− mice. (b) Response to nicotine in +/+ (n = 10), +/− (n = 11), and −/− (n = 8) mice. Data are presented as the contraction in response to nicotine as a percentage of that in response to CCH, ±SEM. (c) Bladder contraction in response to electric field simulation, showing indistinguishable response in +/+ and −/− mice. (d) Bladder contraction in response to CCH in +/+ and −/− mice, indicating comparable responses in the two groups.