Table 4.

Histological Findings in the Stomachs of Gerbils 62 wk after Oral Challenge of H. pylori

Strain:	TN2 (WT)	TN2ΔcagE	TN2ΔvacA	Intact control
No. of animals:	23	27	28	27
Gastritis	23 (100)	27 (100)	28 (100)	0 (0)*
(Severe)	23 (100)	0 (0)*	26 (93)	0 (0)*
Gastric ulcer	22 (96)	0 (0)*	19 (68)**	0 (0)*
Intestinal metaplasia	14 (61)	0 (0)*	15 (54)	0 (0)*
Adenocarcinoma	1 (4)	0 (0)	1 (4)	0 (0)
Carcinoid	1 (4)	0 (0)	5 (18)	0 (0)

Rates are shown as percentages in parentheses. Significant differences against WT infection by means of Fisher's exact probability are indicated as the following: *P < 0.0001 and **P = 0.013.