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. 2000 Mar 20;191(6):985–994. doi: 10.1084/jem.191.6.985

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Prolonged survival of TCR-activated T cells from CIS transgenic mice. (a) TCR-mediated cell death. Concentrations of viable cells were determined in a hemocytometer, and viability was judged by trypan blue exclusion. (b) Reactivation of surviving CD4 T cells after withdrawal of the stimulator, anti-CD3, showing that CIS expression could increase activation and prolong survival of T cell in the absence of stimulator. Anti-CD3 stimulation is indicated by black bars.

Prolonged survival of TCR-activated T cells from CIS transgenic mice. (a) TCR-mediated cell death. Concentrations of viable cells were determined in a hemocytometer, and viability was judged by trypan blue exclusion. (b) Reactivation of surviving CD4 T cells after withdrawal of the stimulator, anti-CD3, showing that CIS expression could increase activation and prolong survival of T cell in the absence of stimulator. Anti-CD3 stimulation is indicated by black bars.