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. 2000 Mar 20;191(6):907–914. doi: 10.1084/jem.191.6.907

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Nonpolymorphic MHC-related molecules are involved in homeostatic maintenance by surveying self-ligands from distinct intracellular compartments. (A) HLA-E presents peptides derived from the signal sequences of class I MHC molecules that are loaded in the endoplasmic reticulum (ER). (B) The neonatal Fc receptor transports IgG from neonatal gut epithelium to blood (not shown), and protects IgG catabolism in adult vascular endothelium, skin, muscle, and gut epithelium. (C) HFE binds iron-bound transferrin on the cell surface of gut epithelium and is trafficked through the endosomal compartment. HFE acts as a negative modulator of transferrin receptor (TfR)-mediated uptake of transferrin (Tf)-bound iron, and thus plays an important role in iron homeostasis.