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. 2000 Apr 17;191(8):1281–1292. doi: 10.1084/jem.191.8.1281

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Mitogen-induced expression of IRF-4 mRNA is markedly reduced in c-rel ^−/− lymphocytes. 10-μg samples of total RNA isolated from untreated or mitogen-stimulated wild-type, nfkb1 ^−/−, or c-rel ^−/− splenocytes activated in culture for 2 h were analyzed by Northern blot hybridization. Filters were sequentially hybridized with murine IRF-4 and rat GAPDH cDNA probes and exposed to autoradiography for 24–48 h. Untreated cells (lane 1) and mitogen-activated cells (lanes 2–7). The stimuli were Con A (lane 2); anti-CD3 plus anti-CD28 antibodies (lane 3); phorbol ester (lane 4); LPS (lane 5); anti-RP antibodies (lane 6); and anti-IgM antibodies (lane 7).