Table 3.

Neuropathological Findings

	CNS region
Animal	Subcortical white matter	Corpus callosum	Optic chiasm, nerves, and tracts	Brain stem, cerebellum	Cervical spinal cord	Thoracic spinal cord	Lumbar spinal cord
rhNGF group
26.30.92	++	+	++	0–+	+	+	0
26.29.94	+	0–+	0–+	0	0	0–+	0–+
UC5.95	0	+	0	0	+	0	0
101	0	0	0	0	+	0	0
231.90	+	0	+	+	+	+	+
FL 5.96	+	++	+	0	0	0	0
Placebo group
26.17.94	+++	++	+++	++	+++	+++	++
26.33.93	+–++	+–++	+++	+–++	+++	+++	++–+++
157.94	0	0	+++	0	++	0	0
198.94	+	0	+	0	+++	++–+++	++
FL 3.95	0	+	++	+	++	0	0
FL 6.96	0	+	0	0	++	0	0

Paired CNS sections were scored using a combined scale for inflammation and demyelination (0 to +++; see Materials and Methods).