Table 4.
Quantitative Immunohistochemistry of Cytokines in the CNS of rhNGF- and Placebo-treated Animals
| Perivascular infiltrates | Normal white matter | ||||
|---|---|---|---|---|---|
| Cytokine examined | No. of infiltrates analyzed/cm2 | No. of stained mononuclear cells/grid | (Percentage of total) | No. of stained glial cells/grid | No. of stained glial cells/grid |
| IFN-γ | |||||
| Placebo | 5.1 ± 2.4 | 14.0 ± 13.0 | (14.6 ± 14.0) | 0 | 0 |
| rhNGF | 1.3 ± 1.5 | 1.8 ± 2.0 | (0.3 ± 0.7) | 0 | 0 |
| P value | 0.004 | 0.020 | (0.020) | – | – |
| IL-10 | |||||
| Placebo | 5.3 ± 2.6 | 7.3 ± 0.1 | (4.8 ± 4.0) | 1.5 ± 1.3 | 1.1 ± 1.6 |
| rhNGF | 3.1 ± 3.8 | 10.0 ± 1.74 | (23.3 ± 16.0) | 24.1 ± 12.0 | 10.1 ± 2.1 |
| P value | 0.050 | 0.400 | (0.036) | 0.007 | <0.0005 |