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. 2000 Apr 3;191(7):1221–1232. doi: 10.1084/jem.191.7.1221

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Cytotoxic T cell responses to murine tyrosinase_369–377 in tyrosinase⁺ and tyrosinase⁻ AAD⁺ mice. Splenocytes from (A) AAD⁺ c^38R145L/c^38R145L mice, (B) AAD⁺ c ⁺/c^38R145L mice, (C) AAD⁺ c ⁺ mice, or (D) AAD⁻ c^38R145L/c^38R145L mice that had been immunized with rvv-mu tyr were cultured for 6 d in the presence of 1 μM FMDGTMSQV. CTL activity was measured on ⁵¹Cr-labeled EL4-AAK (▪, □) or EL4 (•, ○) cells that had been pulsed with 1 μM FMDGTMSQV (filled symbols) or left unpulsed (open symbols). Data are representative of six independent experiments.