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. 2000 Apr 3;191(7):1085–1094. doi: 10.1084/jem.191.7.1085

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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The development of granulocytes, macrophages, B cells, and NK cells is Notch1 independent. (A) Chimeric BM was analyzed for the presence of granulocytes, macrophages, and B cells by staining with mAbs specific for Gr1, Mac-1, and B220. Chimeric spleens were analyzed for the presence of NK cells by staining NK1.1 gated on CD3⁻ cells. The histograms show the expression pattern of these markers in the CD45.2⁺ cells derived from either control (thin line) or induced Notch1^−/− (bold line) BM cells. (B) Absolute cell numbers (×10⁶) for Mac-1⁺, Gr1⁺, B220⁺, and NK1.1⁺(CD3⁻) cells in the CD45.2⁺ fraction derived from either control or induced Notch1^−/− BM cells are calculated and shown as bar diagrams. The bars represent average values, and the triangles represent values from individual mice (n = 8 for both control and induced Notch1^−/− chimeric mice).

The development of granulocytes, macrophages, B cells, and NK cells is Notch1 independent. (A) Chimeric BM was analyzed for the presence of granulocytes, macrophages, and B cells by staining with mAbs specific for Gr1, Mac-1, and B220. Chimeric spleens were analyzed for the presence of NK cells by staining NK1.1 gated on CD3⁻ cells. The histograms show the expression pattern of these markers in the CD45.2⁺ cells derived from either control (thin line) or induced Notch1^−/− (bold line) BM cells. (B) Absolute cell numbers (×10⁶) for Mac-1⁺, Gr1⁺, B220⁺, and NK1.1⁺(CD3⁻) cells in the CD45.2⁺ fraction derived from either control or induced Notch1^−/− BM cells are calculated and shown as bar diagrams. The bars represent average values, and the triangles represent values from individual mice (n = 8 for both control and induced Notch1^−/− chimeric mice).