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. 2000 Nov 20;192(10):1425–1440. doi: 10.1084/jem.192.10.1425

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Particulate accumulation of high MW tracer in cortex after, not during, the initial bolus of soluble tracer in subcapsular sinus. (A) High MW dextran only in subcapsular sinus (arrows) at 5 min after subcutaneous injection. (B) At 30 min, lower intensity signal of high MW dextran in subcapsular sinus (arrows) but high persistent signal in medulla (on right). (C) Control lymph node. (D) Montage of adjacent areas of popliteal lymph node. Focal accumulation of high MW dextran (2,000 kD, fluorescein labeled, green) at 4 h within parenchyma contrasts with reticular-type distribution of low MW dextran (10 kD, Texas red, red) at 10 min (subcapsular sinus, arrows; HEV, arrowheads). However, despite different times of administration, both tracers coaccumulated in a cellular-type distribution within a medullary sinus. Bars, 50 μm.