Table 1.

Binding and Functional Parameters of CCR1, CCR3, and CCR5 for Full Size HCC-1, HCC-1[9–74], and Reference Chemokines for Each Receptor

	CCR1		CCR3		CCR5
Ligand	K i ± SEM	EC50 ± SEM	K i ± SEM	EC50 ± SEM	K i ± SEM	EC50 ± SEM
HCC-1	>100	>1,000	>1,000	>1,000	>1,000	>1,000
HCC-1[9–74]	0.023 ± 0.007	2.8 ± 0.8	2.7 ± 0.8	78 ± 14	0.04 ± 0.01	4.8 ± 1.2
RANTES	ND	6.3 ± 1.1	ND	15 ± 4	0.05 ± 0.01	2.4 ± 0.5
MIP-1α	0.32 ± 0.06	15 ± 5	ND	ND	0.11 ± 0.06	3.3 ± 0.8
MIP-1β	ND	ND	ND	ND	ND	1.3 ± 0.5
Eotaxin	ND	ND	0.31 ± 0.03	2.4 ± 0.4	ND	ND

Values, expressed in nM, are the mean and SEM for at least three independent determinations.