Table 3.
CDR3 Sequences of SecIgM C6 Transcripts and FR3 Mutations in Ox Motif Clones
| Control | Day 4/S | Day 4/A | Day 11/A | Day 88 | Boost | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| JH | JH | M | R | JH | JH | M | R | JH | JH | M | R | ||||||
| DGFAYW | 3 | DDGPYW | 4 | 0 | 0 | WSFAYW | 3 | DRGAYW | 3 | 0 | 0 | TGFDYW | 2 | DGGDYW | 4 | 1 | 0 |
| DGFAYW | 3 | TGFDYW | 2 | DGFAYW | 3 | DGGNSW | 4 | 0 | 0 | WGFAYW | 3 | DWGAYW | 3 | 2 | 1 | ||
| DQFAYW | 3 | TVVDYW | 2 | DTFAYW | 3 | DRGDYW | 2 | na | na | WGFAYW | 3 | DGGDYW | 4 | 1 | 0 | ||
| TGFDYW | 2 | IAMDYW | 4 | DRRDYW | 4 | DGGDYW | 2 | 0 | 0 | GGYHYW | 2 | DGGDYW | 4 | 1 | 0 | ||
| GTLDYW | 2 | DGNYYW | 2 | TGFDYW | 2 | NGFDYW | 2 | WGFAYW | 3 | DGGDYW | 4 | 3 | 2 | ||||
| WAFAYW | 3 | WRFAYW | 3 | AWDNYW | 2 | DGSAYW | 4 | RGFAYW | 3 | DGGDYW | 4 | 1 | 0 | ||||
| WGFAYW | 3 | WGFAYW | 3 | WGFAYW | 3 | TGFDYW | 2 | DRGDYW | 2 | 2 | 1 | ||||||
| DGFAYW | 3 | EGFAYW | 3 | EGIAYW | 3 | DGFAYW | 3 | DGGDYW | 4 | 1 | 0 | ||||||
| NAMDYW | 4 | EGIAYW | 3 | GPFDYW | 2 | DGGAYW | 3 | 0 | 0 | ||||||||
| DGFAYW | 3 | DGFAYW | 3 | TGFDYW | 2 | DGGDYW | 4 | 1 | 0 | ||||||||
| DGNYYW | 2 | DGFAYW | 3 | AGFDYW | 2 | DRGVYW | 3 | 0 | 0 | ||||||||
| WGFAYW | 3 | GNLAYW | 3 | TGFDYW | 2 | DGGDYW | 4 | 1 | 0 | ||||||||
| LGFDYW | 2 | WAMDYW | 4 | TGGIYW | 2 | DGGDYW | 4 | 1 | 0 | ||||||||
| WLLDYW | 2 | DGFAYW | 3 | TGFDYW | 2 | DGGDYW | 4 | 0 | 0 | ||||||||
| WGFAYW | 3 | YAMDYW | 4 | LYYGNW | 2 | DRGVYW | 2 | 2 | 1 | ||||||||
| YAMDYW | 4 | TGFDYW | 2 | WAFAYW | 3 | DGGDYW | 4 | 1 | 0 | ||||||||
| WDVDYW | 2 | DGGDYW | 4 | 1 | 0 | ||||||||||||
| TGGIYW | 2 | WGFAYW | 3 | ||||||||||||||
| DTFAYW | 3 | ||||||||||||||||
| WGFAYW | 3 | ||||||||||||||||
| WGFAYW | 3 | ||||||||||||||||
Column headings are as for Fig. 3 and Fig. 5. Ox motif sequences are underlined. M, total number of mutations found in the FR3 region of the corresponding Ox motif clone; R, number of mutations causing an amino acid replacement; na, FR3 sequence not analyzable; S, soluble antigen; A, alum/pertussis adjuvant.