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Agg Ig-PLP1 modulates disease involving intra- and intermolecular epitopes. Groups of SJL/J mice (nine per group) were induced for EAE with 6 mg of CNS homogenate and on days 9, 13, and 17 treated intraperitoneally with 300 μg agg Ig-PLP1 or agg Ig-W per injection. A group of untreated mice (NIL) was included for comparison purposes.
