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. 2000 Jun 19;191(12):2039–2052. doi: 10.1084/jem.191.12.2039

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Requirement for a physical linkage of the Ig vehicle to PLP1 peptide for amelioration of EAE. Groups of mice (eight per group) were induced for EAE with 100 μg PLP1, and then treated with 300 μg of agg Ig-PLP1 (agg Ig-PLP1), 300 μg agg Ig-W (agg Ig-W), or 300 μg agg Ig-W plus 100 μg PLP1 (agg Ig-W + PLP1) in PBS on days 9, 13, and 17 after disease induction. The onset of disease was at day 7 in these experimental groups.