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. 2000 Jun 19;191(12):2171–2182. doi: 10.1084/jem.191.12.2171

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Clearance and hepatic uptake of mildly reduced and alkylated IgA. (A) Clearance from the circulation of 1 μg of mildly reduced and alkylated IgA1, IgA2m(1), IgA2m(2), and IgA2(n). The IgA remaining in blood was determined as described in the legend to Fig. 3. Each data point is the mean ± SD for three normal mice. The superimposed dotted gridlines highlight the time (t _50%) required for the disappearance of 50% of the administered dose. (B) Hepatic uptake represented as the percentage of the injected dose of radioactivity measured in the blood-free liver at 10 min.