Figure 5.

Clearance from the serum of IgA1, IgA2m(1), IgA2m(2), and IgA2(n) in ASGR^−/− knockout mice and in wild-type (WT) mice in the presence and absence of the ASGR ligand galactose-Ficoll. Trace amounts of radiolabeled IgA (1 μg) were injected into the tail vein of mice and at the indicated time points, the IgA remaining in blood was determined as described in the legend to Fig. 3. To inhibit ASGR uptake in wild-type mice, 1 mg of galactose-Ficoll was simultaneously administered with the radiolabeled IgA.