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Sex-related Differences in PAF-induced Anaphylaxis
| Genotype: | BLTR+/+ | BLTR−/− | ||
|---|---|---|---|---|
| Sex | Male | Female | Male | Female |
| Survivors/total | 3/11 | 1/9 | 1/11 | 6/9 |
Mice were injected intravenously with PAF at a dose of 200 μg/kg body weight and observed for 24 h. The total number of animals tested for each genotype and sex is shown separately with the number of surviving animals. The difference in mortality between female and male BLTR−/− mice is statistically significant (P = 0.002, Fisher's exact test).
