Table 1.
Clearance of Leishmania Is Defective in IRF-2–deficient Mice
| Organ | No. of weeks after infection | C57BL/6+/+ | IRF-2+/− | IRF-2−/− |
|---|---|---|---|---|
| Footpad | 4 | 5.0 × 105 ± 2.5 × 105 | 2.5 × 105 ± 1.7 × 105 | 2.5 × 107 ± 1.5 × 107 |
| 7 | 7.8 × 105 ± 7.3 × 105 | 1,600 ± 800 | 4.0 × 106 ± 3.5 × 106 | |
| LN | 4 | 1,900 ± 400 | 1,200 ± 500 | 1.6 × 104 ± 1.1 × 104 |
| 7 | 35 ± 13 | 108 ± 64 | 1.1 × 105 ± 0 | |
| Spleen | 4 | 1 ± 1 | 10 ± 8 | 1,500 ± 1,200 |
| 7 | 2 ± 1 | 240 ± 96 | 1.5 × 106 ± 3.0 × 105 |
Parasite burden in the infected footpad, popliteal LN draining the infected footpad, or spleen of individual wild-type C57BL/6, IRF-2+/−, or IRF-2−/− mice (four mice per group) 4 and 7 wk after L. major infection. Results are given as the number of parasites in the footpad, LN, and spleen of the respective mice. Data represent the mean ± SD of all mice in one group and are representative of three separate experiments.