Table 1.
Cytokine Secretion Profile of Myc-responsive TCCs from IL-12Rβ1–deficient Patients
| Antigen-specific stimulation | Stimulation with anti-CD3/PMA | |||
|---|---|---|---|---|
| TCCs | IFN-γ | IL-4 | IFN-γ | IL-4 |
| Patients | ||||
| S8A5 | 226 | <7 | 6,300 | <7 |
| S3E8 | 554 | 25 | 109,915 | 54 |
| S7C4 | 649 | <25 | 13,700 | 16 |
| S8D3 | 1,119 | <25 | 6,827 | 33 |
| K2B10 | 1,063 | <25 | 26,036 | 252 |
| K8D1 | 426 | 8 | 31,400 | 4 |
| K3F12 | 365 | <7 | 49,500 | <7 |
| K8D10 | 2,129 | <7 | 26,400 | <7 |
| K4D4 | 246 | <25 | 5,563 | 36 |
| K2E9 | 4,559 | 23 | 2,900 | 154 |
| Controls | ||||
| R1E4 | 12,125 | 113 | 97,569 | 112 |
| R2F10 | 1,449 | 30 | 88,868 | 1,244 |
10-d–rested TCCs from P1 (indicated by S), P3 (indicated by K), and two control TCCs (R1E4 and R2F10) were stimulated with mycobacterial sonicates (M. avium or M. leprae), or with CD3/PMA. 24-h supernatants were then collected and analyzed for their IFN-γ and IL-4 production by ELISA. Data are given in pg/ml.