Table 1.
NFATp−/− Mice Are Resistant to SEB-induced T Cell–mediated Lethal Shock, but Not to LPS-stimulated Lethal Shock
| D-Gal | LPS | SEB | TNF-α | Lethality | |
|---|---|---|---|---|---|
| NFATp+/+ | NFATp−/− | ||||
| mg/mouse | μg/mouse | dead/total | |||
| 20 | – | – | – | 0/3 | |
| – | 100 | – | – | 0/3 | |
| 20 | 10 | – | – | 5/5 | 5/5 |
| 20 | 1 | – | – | 5/5 | 3/3 |
| 20 | 0.1 | – | – | 8/12 | 6/9 |
| 20 | 0.01 | – | – | 0/3 | 0/3 |
| – | – | 200 | – | 0/3 | |
| – | – | 100 | – | 0/3 | |
| 20 | – | 100 | – | 3/3 | 3/3 |
| 20 | – | 10 | – | 4/4 | 3/4 |
| 20 | – | 5 | – | 14/14 | 0/9 |
| 20 | – | 2 | – | 4/7 | 0/6 |
| – | – | – | 1 | 0/3 | 0/3 |
| 20 | – | – | 1 | 4/4 | 4/4 |
| 20 | – | – | 0.1 | 3/6 | 4/6 |
| 20 | – | – | 0.01 | 0/6 | 0/6 |
Female mice received the indicated dosage of D-Gal, LPS, SEB, or recombinant murine TNF-α intraperitoneally in 0.5 ml pyrogen-free 0.9% NaCl. Surviving mice were monitored for 1 wk after injection. None of the mice that survived for 24 h after injection died later.