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HMG-1 stimulates the expression of cytokines and chemokines in human PBMCs. Human PBMCs were cultured with either rHMG-1 (1 μg/ml) plus polymyxin B (10 μg/ml) or LPS alone (100 ng/ml). Cells were harvested in longitudinal studies, fixed, and stained using indirect immunofluorescence. Monocytes were the only cells contributing to the synthesis of the studied mediators, confirmed by two-color staining. *P < 0.05 vs. LPS.
