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. 2000 Jul 17;192(2):205–218. doi: 10.1084/jem.192.2.205

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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CCR2^−/− mice showed marked sensitivity to L. major infection. (A) Thickness of the ears of wild-type (+/+; ○), CCR2^−/− (•), CCR5^−/− (▴), or MIP-1α^−/− (▪) mice after intradermal inoculation of L. major. Results are the mean ± SD for 10 mice (2 d and 1 wk) or 5 mice (2, 3, 4, and 5 wk). (B–D) Parasite burden in the ears, draining lymph nodes, and spleens. Results are the mean ± SD for five mice, and are from one of two representative experiments. *P < 0.05 and **P < 0.01, difference from +/+ mice.