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. 2000 Jul 17;192(2):271–280. doi: 10.1084/jem.192.2.271

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Impaired virus-specific IgG response in the absence of sIgM. Groups of 3-mo-old sIgM^−/− and sIgM^+/+ mice (n = 10) were infected with influenza virus Mem71. Mice were bled at indicated times, and the titers of influenza virus–specific IgM, IgG1, and IgG2a were measured by ELISA. Arbitrary units of antivirus Ig per milliliter were determined by comparison to a standard hyperimmune serum.