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. 2000 Jul 17;192(2):271–280. doi: 10.1084/jem.192.2.271

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Reconstitution of natural IgM–deficient chimeras results in increased survival and increased antiviral IgG2a serum titers after influenza virus infection. Lethally irradiated recipients were reconstituted with bone marrow from wild-type mice and PerC cells from sIgM^−/− mice (B-1 sIgM^−/−). Chimeras received daily injections of 0.5 ml of normal serum (sIgM^+/+ serum; n = 10) or IgM-deficient serum (sIgM^−/− serum; n = 10) immediately before infection and daily for 5 d after infection. Control mice received both bone marrow and PerC cells from sIgM^+/+ mice (B-1 sIgM^+/+). (A) Survival from infection with influenza A/Mem71 was monitored daily for 28 d. (B) Mem71-binding serum IgM titers were determined by ELISA in groups (n = 9) of noninfected chimeras after 3 d of daily injections with the indicated type of serum or in controls. Arbitrary units of antivirus Ig per milliliter are shown. (C) Mem71-specific IgG2a titers in the sera of indicated groups of irradiation chimeras were determined at day 8 after infection with influenza A/Mem71 by ELISA. Arbitrary units of antivirus Ig per milliliter are shown.