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. 2000 Jul 17;192(2):183–192. doi: 10.1084/jem.192.2.183

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Galgp, but not other mucins, enables CD43^−/− Mφ to bind M. avium. M. avium at a bacteria/cell ratio of 2:1 were incubated with CD43^−/− Mφ in the absence (none) or presence of Galgp, AFGP, or PSM reduced and trypsin-treated (PSM-RT) at 100 μg/ml. After 4 h, the cells were washed and the mycobacteria associated with cells were quantified. Shown are mean values ± SEM for cells from three mice. The number of M. avium associated with the CD43^−/− Mφ incubated with the mycobacteria in the presence of Galgp, AFGP, or PSM were significantly different (P < 0.0001). Similar effects of mucin treatments were seen in one additional experiment.