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. 2000 Jul 17;192(2):159–170. doi: 10.1084/jem.192.2.159

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© 2000 The Rockefeller University Press

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Morphological and cytological changes in the lungs of ADA-deficient mice. (a) H&E-stained control lung at postpartum day 18. (b) H&E-stained ADA-deficient lung at postpartum day 18. Arrows indicate areas of inflammation. Notice the pronounced enlargement of alveolar spaces (AS) and the thickening of pulmonary blood vessels (BV). (c) High magnification of an H&E-stained ADA-deficient lung demonstrating eosinophil infiltration (arrows) around bronchioles (B) and pulmonary blood vessels (BV). (d) Immunolocalization of eosinophils in an 18-d-old ADA-deficient lung, using a rabbit polyclonal antibody raised against mMBP-1 followed by detection with FITC immunofluorescence. Notice intense staining of inflammatory cells with anti–MBP-1 (arrows). mMBP-1 immunoreactivity was also detected in alveolar macrophages (AM). Cytological analysis of cells collected from BALF from the lung of an 18-d-old ADA-deficient mouse showing (e) eosinophils (arrows), (f) alveolar macrophages engulfing eosinophils (arrows), and (g) multinucleated giant cells. Bars, (a–d) 100 μm; (e–g) 10 μm.