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. 2000 Jul 17;192(2):249–258. doi: 10.1084/jem.192.2.249

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© 2000 The Rockefeller University Press

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(continues on facing page). S. typhimurium induces inflammation in wild-type PP but not in casp-1 ^−/ − PP. Transmission electron micrographs of infected PP revealed bacterial invasion of M cells at 0.5 h in wild-type (a) and casp-1 ^−/ − (b) PP, and at 1 h in (c) extracellular Salmonella in wild-type and (d) intracellular bacteria in casp-1 ^−/ − PP. At 3 h, wild-type PP dome revealed an infiltration of PMNs and intracellular Salmonella (e), whereas casp-1 ^−/ − PP revealed an absence of PMNs and bacteria (f). Hematoxylin and eosin stains of PP from casp-1 ^+/+ (g) mice infected for 3 h revealed clusters of PMNs (black arrows) and pyknotic cells (arrowheads), whereas casp-1 ^−/ − PP did not (h). Uninfected, wild-type PP are shown for comparison (i). Yellow arrows point to the PP dome area. Serial tissue sections were stained with anti-Salmonella antibody to confirm that the PP shown was infected. All sections are oriented with intestinal lumen at the top and lymphoid follicle at the bottom.

(continues on facing page). S. typhimurium induces inflammation in wild-type PP but not in casp-1 ^−/ − PP. Transmission electron micrographs of infected PP revealed bacterial invasion of M cells at 0.5 h in wild-type (a) and casp-1 ^−/ − (b) PP, and at 1 h in (c) extracellular Salmonella in wild-type and (d) intracellular bacteria in casp-1 ^−/ − PP. At 3 h, wild-type PP dome revealed an infiltration of PMNs and intracellular Salmonella (e), whereas casp-1 ^−/ − PP revealed an absence of PMNs and bacteria (f). Hematoxylin and eosin stains of PP from casp-1 ^+/+ (g) mice infected for 3 h revealed clusters of PMNs (black arrows) and pyknotic cells (arrowheads), whereas casp-1 ^−/ − PP did not (h). Uninfected, wild-type PP are shown for comparison (i). Yellow arrows point to the PP dome area. Serial tissue sections were stained with anti-Salmonella antibody to confirm that the PP shown was infected. All sections are oriented with intestinal lumen at the top and lymphoid follicle at the bottom.