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. 2000 Jul 17;192(2):249–258. doi: 10.1084/jem.192.2.249

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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S. typhimurium CFU decrease in casp-1 ^−/ − PP. Ligated intestinal loops were performed for 0.5 and 3 h and gentamicin-protected CFU per PP was determined. Lanes 1 (n = 9) and 5 (n = 10), casp-1 ^+/+ mice infected with SL1344. Lanes 2 (n = 9) and 6 (n = 11), casp-1 ^+/+ mice infected with noninvasive mutant BJ66 3. Lanes 3 (n = 10) and 7 (n = 13,) casp-1 ^−/ − mice infected with SL1344. Lanes 4 (n = 12) and 8 (n = 12), casp-1 ^−/ − mice infected with BJ66. Unpaired t test revealed P < 0.0001 and P = 0.0013 for SL1344 in casp-1 ^−/ − compared with casp-1 ^+/+ at 0.5 and 3 h, respectively; P = 0.0001 for SL1344 in casp-1 ^+/+ mice for 0.5 versus 3 h; P = 0.0028 for SL1344 in casp-1 ^−/ − mice for 0.5 versus 3 h. The noninvasive mutant produced numbers that were not statistically different between the two mouse strains. The mean and standard deviations are shown from two separate experiments.