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. 2000 Jul 17;192(2):295–302. doi: 10.1084/jem.192.2.295

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Regulation of colitis by CD25⁺CD4⁺ cells is TGF-β dependent. SCID mice received CD45RB^highCD4⁺ cells alone (□) or in combination with 10⁵ CD25⁺ cells (▵). Mice also received either anti–TGF-β (filled symbols) or PBS (open symbols). Significant protection mediated by CD25⁺ cells (P < 0.01) abrogated by treatment with anti–TGF-β mAb (P < 0.02).