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. 2000 Jul 17;192(2):295–302. doi: 10.1084/jem.192.2.295

Figure 4.

Figure 4

Regulation of colitis by CD25+CD4+ cells is TGF-β dependent. SCID mice received CD45RBhighCD4+ cells alone (□) or in combination with 105 CD25+ cells (▵). Mice also received either anti–TGF-β (filled symbols) or PBS (open symbols). Significant protection mediated by CD25+ cells (P < 0.01) abrogated by treatment with anti–TGF-β mAb (P < 0.02).