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. 2000 Sep 5;192(5):755–760. doi: 10.1084/jem.192.5.755

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© 2000 The Rockefeller University Press

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graphic file with name JEM000347.f1a.jpg — Perforin protects mice from spontaneous lymphomas. The appearance of tumors was recorded in mice derived from a pfp^+/−p53^+/− intercross. Groups of mice (n = 16–34) were evaluated on a weekly basis and when moribund, tumor type (□, thymic lymphoma; ▪, disseminated lymphoma; ▴, sarcoma; ○, other tumors) recorded against the age at time of death/autopsy (in days). The perforin genotype (pfp^−/−, pfp^+/−, or pfp^+/+) is also displayed on the x-axis. (A) p53^+/+, (B) p53^+/−, or (C) p53^−/−. The MA of p53^−/− mice developing disseminated lymphoma is depicted by the crossbar in C. All p53^−/− mice studied developed tumors and the numbers of p53^+/− and p53^+/+ mice developing lymphomas are shown in parentheses. In D, the percentage of pfp^−/− and pfp^+/+ mice free of disseminated lymphoma (from A and B) are plotted against their age at time of death in days, and P values (Fisher's exact test) comparing the proportions of disseminated lymphoma between pfp^−/− and pfp^+/+ mice are indicated.

graphic file with name JEM000347.f1b.jpg — Perforin protects mice from spontaneous lymphomas. The appearance of tumors was recorded in mice derived from a pfp^+/−p53^+/− intercross. Groups of mice (n = 16–34) were evaluated on a weekly basis and when moribund, tumor type (□, thymic lymphoma; ▪, disseminated lymphoma; ▴, sarcoma; ○, other tumors) recorded against the age at time of death/autopsy (in days). The perforin genotype (pfp^−/−, pfp^+/−, or pfp^+/+) is also displayed on the x-axis. (A) p53^+/+, (B) p53^+/−, or (C) p53^−/−. The MA of p53^−/− mice developing disseminated lymphoma is depicted by the crossbar in C. All p53^−/− mice studied developed tumors and the numbers of p53^+/− and p53^+/+ mice developing lymphomas are shown in parentheses. In D, the percentage of pfp^−/− and pfp^+/+ mice free of disseminated lymphoma (from A and B) are plotted against their age at time of death in days, and P values (Fisher's exact test) comparing the proportions of disseminated lymphoma between pfp^−/− and pfp^+/+ mice are indicated.