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. 2000 Sep 5;192(5):705–718. doi: 10.1084/jem.192.5.705

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Maturing DC-LAMP⁺ LCs are strongly increased in lesional psoriatic skin. The stage of DC maturation was determined according to the expression by immunohistochemistry of two DC-specific markers, Langerin and DC-LAMP. Immature LCs (DC-LAMP⁻Langerin⁺, present in epidermis only), maturing LCs (DC-LAMP⁺Langerin⁺, present in epidermis and dermis), and mature DCs (DC-LAMP⁺ Langerin⁻, present in dermis only) were counted in three randomly selected fields (original magnification: ×100) per section. Each count was performed on two or three serial sections, and results were expressed as the mean ± SD of DCs per three fields. Results from three to four independent normal donor and patients are shown. PSO., psoriatic.