Table 1.
Distribution of TSLPRs
| TSLP bound (molecules/cell) | |||
|---|---|---|---|
| Cell line | Characteristic | High K a | Low K a |
| Murine cells | |||
| Nag8/7 | TSLP-dependent pre-B cell | 500–1,700 | nd |
| 70Z3 | Pre-B cell | 300–3,000 | nd |
| IxN/2B | IL-7–dependent pre-B cell | 700–1,500 | nd |
| NFS-25-C3 | Pre-B lymphoblast | 440 | nd |
| NFS-5-C1 | Pre-B lymphoblast | 480 | nd |
| BAF/BO3 | Pre-B cell | nd | 250–2,500 |
| Wehi 279 | B cell | nd | nd |
| 7B9 | T cell clone (helper) | 500–1,800 | nd |
| CTLL | IL-2–dependent T cell | nd | nd |
| EL-4 | T cell thymoma | nd | nd |
| LSTRA | T lymphocytic leukemia | 35 | 7,500 |
| FDCP-2 | Myeloid | nd | nd |
| FDCP-1 | Promyeloid | nd | 210 |
| PU5-1.8 | Macrophage | 1,000 | nd |
| P388D1 | Macrophage | nd | nd |
| J774 | Macrophage | nd | 300 |
| Raw 264.7 | Monocytic | nd | nd |
| NS1.1 | Monocytic | 100 | 1,400 |
| P815 | Mastocytoma | 20 | 1,300 |
| MC-6 | Mast cell | nd | 540–2900 |
| DA-1 | Mast cell | nd | nd |
| Human cells | |||
| JM-1 | Pre-B cell | nd | nd |
| EU.1 | Pre-B cell | nd | nd |
| Daudi | B cell lymphoma | nd | nd |
| Raji | B cell lymphoma | nd | nd |
| CB23 | B cell lymphoma | nd | nd |
| MP-1 | B cell lymphoma | nd | nd |
| THP-1 | Monocytic | nd | nd |
| U937 | Monocytic | nd | nd |
| MO7E | Premegakaryocytic | nd | nd |
| TF-1 | Proerythrocytic | nd | nd |
| KG-1 | Myelogenous leukemia | nd | nd |
| W126 | Lung fibroblast | nd | nd |
| IMTLH | Stromal | nd | nd |
Binding experiments were conducted as described in Materials and Methods. Molecules bound per cell were determined by Scatchard analysis of complete sets of binding data and represent total sites per cell.