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Schematic representation of PML traffic onto NBs. Under our working model, PML is initially dispersed in the nucleoplasm possibly in the chromatin. A specific dephosphorylation event triggered by As2O3 targets PML to the nuclear matrix on primary PML bodies. Sumolation then induces the maturation to secondary PML bodies that contain the 11S proteasome subunits α and β, Daxx, and Sp100, where PML would be degraded.
