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. 2000 Oct 2;192(7):1035–1046. doi: 10.1084/jem.192.7.1035

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© 2000 The Rockefeller University Press

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Caspase-1–deficient macrophages are not resistant to apoptosis induced by invasive Salmonella. Primary bone marrow–derived macrophages isolated from wt caspase-1–deficient mice were stained with CM-X-ROS and DAPI and infected with wt Salmonella or with the invasion-defective invA ⁻ and sipB ⁻ strains (m.o.i 25) as described in the legend to Fig. 1. (A) Caspase-1–deficient macrophages were infected with wt Salmonella or with the invasion-defective invA ⁻ and sipB ⁻ strains. The percentage of cells containing condensed chromatin was determined as described in the legend to Fig. 1, 25 min (open bars) and 4 h (closed bars) after infection. UT, untreated cells. The SD was <5% in all cases, and it has been omitted. (B) Photomicrographs of caspase-1–deficient macrophages infected with Salmonella.

Caspase-1–deficient macrophages are not resistant to apoptosis induced by invasive Salmonella. Primary bone marrow–derived macrophages isolated from wt caspase-1–deficient mice were stained with CM-X-ROS and DAPI and infected with wt Salmonella or with the invasion-defective invA ⁻ and sipB ⁻ strains (m.o.i 25) as described in the legend to Fig. 1. (A) Caspase-1–deficient macrophages were infected with wt Salmonella or with the invasion-defective invA ⁻ and sipB ⁻ strains. The percentage of cells containing condensed chromatin was determined as described in the legend to Fig. 1, 25 min (open bars) and 4 h (closed bars) after infection. UT, untreated cells. The SD was <5% in all cases, and it has been omitted. (B) Photomicrographs of caspase-1–deficient macrophages infected with Salmonella.