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. 2000 Oct 2;192(7):953–964. doi: 10.1084/jem.192.7.953

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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BLyS enhances activated B cell expansion and reduces apoptosis in vivo and in vitro. (A) Spleens were weighed (weights shown in grams) on day 8 of NP-CGG immunization, with coinjection of PBS (○) or 10 μg/mouse BLyS (•). (B) Viable splenic B cells in PBS and BLyS–coinjected mice were determined on day 8 of NP-CGG immunization (n = 3). (C) Annexin V binding of high density (H) and low density (L) splenic B cells isolated on day 11 after immunization with NP-CGG and coinjected with PBS (○) or 10 μg/mouse BLyS (•) (n = 3). (D) Annexin V binding of low density splenic B cells were isolated on day 8 of NP-CGG–immunized mice, coinjected with PBS or BLyS as indicated, and cultured in vitro for 24 h in media alone (○) or with 100 ng/ml BLyS, n = 3 (•). (E) Expression of CD40 and Fas on high (H) and low density (L) B cells without immunization (C), or on day 8 after immunization with NP-CGG coinjected with PBS or BLyS. These experiments have been performed three times.