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. 2000 Oct 2;192(7):1001–1014. doi: 10.1084/jem.192.7.1001

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© 2000 The Rockefeller University Press

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Scavenging the ROS trigger or exposure to exogenous NO inhibits the MPT. Cells loaded with 125 nM TMRM and confocal line-scan–imaged at 2 Hz. (A) Mean time to MPT induction in control versus pretreated cells as indicated: Trolox (2 mM); SNAP (100 μM); L-NAME (1 mM). Data represent the average from 8–10 cells in each group. (B) Evidence of endogenous production of NO by mitochondria after MPT induction and inhibition by L-NAME (4 mM). Myocytes were loaded with 125 nM TMRM (red) and 10 mM DAF-2 (green) and line scanned at 100 Hz.

Scavenging the ROS trigger or exposure to exogenous NO inhibits the MPT. Cells loaded with 125 nM TMRM and confocal line-scan–imaged at 2 Hz. (A) Mean time to MPT induction in control versus pretreated cells as indicated: Trolox (2 mM); SNAP (100 μM); L-NAME (1 mM). Data represent the average from 8–10 cells in each group. (B) Evidence of endogenous production of NO by mitochondria after MPT induction and inhibition by L-NAME (4 mM). Myocytes were loaded with 125 nM TMRM (red) and 10 mM DAF-2 (green) and line scanned at 100 Hz.