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. 2000 Oct 2;192(7):1001–1014. doi: 10.1084/jem.192.7.1001

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© 2000 The Rockefeller University Press

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Altered MPT characteristics after modulation of the redox state of soluble and protein thiols. (A) Comparison of MPT times (during 2 Hz line-scan imaging in TMRM-loaded cells) and cellular glutathione content in control versus 600 μM diethylmaleate-treated cells. (B) Development of apparent unstable MPT pore flickering during 2 Hz line-scan imaging in a representative TMRM-loaded (125 nM) cell exposed to 5 mM diethylmaleate. Arrows indicate movement artifacts.

Altered MPT characteristics after modulation of the redox state of soluble and protein thiols. (A) Comparison of MPT times (during 2 Hz line-scan imaging in TMRM-loaded cells) and cellular glutathione content in control versus 600 μM diethylmaleate-treated cells. (B) Development of apparent unstable MPT pore flickering during 2 Hz line-scan imaging in a representative TMRM-loaded (125 nM) cell exposed to 5 mM diethylmaleate. Arrows indicate movement artifacts.