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. 2001 Jan 15;193(2):219–232. doi: 10.1084/jem.193.2.219

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© 2001 The Rockefeller University Press

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Early lymphocytosis in IL-15tg mice. (a and b) Total white blood cell (WBC) and lymphocyte counts in IL-15tg (n = 71) and nontransgenic littermate control (n = 51) at 6 wk of age. Graphs show the mean ± SEM, with a significant increase in both the absolute white blood cell (*, P < 10⁻⁷) and lymphocyte counts (**, P < 10⁻⁸) in IL-15tg mice. (c and d) Representative photomicrographs at low (40×) and high (100×) magnification of peripheral blood smears from a 6-wk-old IL-15tg mouse (IL-15tg) and a nontransgenic littermate control (WT Control). Note expansion of large granular lymphocytes in IL-15tg mouse smear.

Early lymphocytosis in IL-15tg mice. (a and b) Total white blood cell (WBC) and lymphocyte counts in IL-15tg (n = 71) and nontransgenic littermate control (n = 51) at 6 wk of age. Graphs show the mean ± SEM, with a significant increase in both the absolute white blood cell (*, P < 10⁻⁷) and lymphocyte counts (**, P < 10⁻⁸) in IL-15tg mice. (c and d) Representative photomicrographs at low (40×) and high (100×) magnification of peripheral blood smears from a 6-wk-old IL-15tg mouse (IL-15tg) and a nontransgenic littermate control (WT Control). Note expansion of large granular lymphocytes in IL-15tg mouse smear.