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. 2001 Jan 15;193(2):219–232. doi: 10.1084/jem.193.2.219

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© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Early expansion of CD8⁺ T cells within IL-15tg mice. (a) Flow cytometric analysis of peripheral blood lymphocytes from representative IL-15tg and nontransgenic littermate wild-type controls (WT). Most lymphocytes in wild-type mice are CD3⁺TCR-β⁺ T cells, and the percentage of this population is reduced in IL-15tg mice due to dilution by the expanded NK cells. The CD4/CD8 ratio is significantly inverted in IL-15tg mice. (b) The absolute number of CD4⁺ T cells is identical in IL-15tg and control mice. (c) The absolute number of CD8⁺ T cells is significantly increased in IL-15tg (P < 10⁻⁴), compared with control mice. This increase in CD8⁺ T cells is responsible for the CD4/CD8 ratio. For b and c, data represent the mean CD4 or CD8 counts ± SEM of IL-15tg (n ± 71) and control (n = 51) mice.