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. 2000 Nov 6;192(9):1317–1326. doi: 10.1084/jem.192.9.1317

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Splenocytes from influenza-primed mice do not kill RSV-infected targets. Spleens from RSV- or influenza-infected mice were removed after 14 d and disrupted to a single cell suspension. After 5 d in the presence of 2 PFU/cell of RSV or 1 HA unit of influenza virus, remaining cells were assessed for cytotoxic activity. RSV-immune mice effectively killed RSV-infected targets (♦). Influenza-immune splenocytes similarly killed influenza (▴) but not RSV-infected (▪) targets. (B) Influenza tetramer–positive cells were purified from the lung and mediastinal lymph nodes of 10 influenza-infected and RSV-challenged mice using avidin-coated magnetic beads and MACS. A cytotoxicity assay with influenza- (•) or RSV- (⋄) infected P815 cells was then performed. Spontaneous release has been subtracted from all results and never exceeded 10% of maximal chromium release.

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