Table 2.

Spontaneous Autoantibody Production in 10-mo-old Mice

	B6		B6/129.Igh b		Cr2 −/−		C4 +/−		C4 −/−
	female	male	female	male	female	male	female	male	female	male
n	30	20	33	23	23	45	21	20	38	21
ANA percent positive	30	15	27	35	43	31	38	25	100	67
Range (titer)	0–360	0–120	0–360	0–360	0–1,080	0–360	0–1,080	0–360	120–29,160	0–9,720
Median	0	0	0	0	0	0	0	0	1,080	120
χ2 (P)	ns	ns	–	–	ns	ns	ns	ns	<0.00001	<0.05
Anti-ssDNA percent positive	13	0	18	13	22	9	10	0	84	29
Range (μg/ml)	0–11	0	0–150	0–32	0–38	0–10	0–4	0	0–286	0–357
Median	0	0	0	0	0	0	0	0	13	0
χ2 (P)	ns	ns	–	–	ns	ns	ns	ns	<0.00001	ns
Anti-dsDNA percent positive	7	0	15	4	26	7	14	5	76	14
Range (μg/ml)	0–12	0	0–150	0–30	0–55	0–12	0–5	0–3	0–318	0–260
Median	0	0	0	0	0	0	0	0	5	0
χ2 (P)	ns	ns	–	–	ns	ns	ns	ns	<0.00001	ns
Anti-nDNA percent positive	10	0	9	4	9	7	0	0	58	14
Range (titer)	0–20	0	0–20	0–10	0–20	0–20	0	0	0–160	0–80
Median	0	0	0	0	0	0	0	0	10	0
χ2 (P)	ns	ns	–	–	ns	ns	ns	ns	<0.00005	ns